For instance, gold in bulk form is inert and conducts electricity, however gold shrunk into “nano” form becomes a very good catalyst and turns into a semiconductor instead. The materials assume novel mechanical, chemical, electrical, optical, magnetic, electro-optical, and magneto-optical properties as compared to bulkier counterparts.
The breakthroughs achieved in the field of nanoscience are mainly attributable to the changes in the properties of materials as they are reduced to the size of nanometer from their bulk form. Nanoscience is recognized as a promising field of science that can overcome several scientific shortcomings in diverse scientific fields, such as physics, biology, chemistry, and materials science. Apart from that, the effect of ignored factors at the bio-nano interface such as temperature, plasma concentration, plasma gradient effect, administration route, and cell observer were also addressed. The main aim of this review is to present different factors that are influencing protein-nanoparticle interaction such as physicochemical properties of nanoparticle ( i.e., size and size distribution, shape, composition, surface chemistry, and coatings) and the effect of biological microenvironments. As such, much emphasis should be placed in understanding these complex phenomena that occur at the bio-nano interface. For instance, protein corona formation on the surface of nanoparticles can modify its physicochemical properties and interfere with its intended functionalities in the biological microenvironments.
Protein corona has became a prevalent subject in the field of nanomedicine owing to its diverse role in determining the efficiency, efficacy, and the ultimate biological fate of the nanomaterials used as a tool to treat and diagnose various diseases.
0 kommentar(er)
